James McAvoy

Patricia / Dennis / Hedwig / The Beast / Barry / Heinrich / Jade / Ian / Mary Reynolds / Norma / Jalin / Kat / B.T. / Kevin Wendell Crumb / Mr. Pritchard / Felida / Luke / Goddard / Samuel / Polly

Bruce Willis

David Dunn / The Overseer

Samuel L. Jackson

Elijah Price / Mr. Glass

Sarah Paulson

Dr. Ellie Staple

Anya Taylor-Joy

Casey Cooke

Spencer Treat Clark

Joseph Dunn

Charlayne Woodard

Mrs. Price

Luke Kirby

Pierce

Adam David Thompson

Daryl

M. Night Shyamalan

Jai, Security Guard